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- Introduction to Metris
- LABORAS
- SONOTRACK
- Automation
- Examples
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- 5/1999 Metris BV start
- 9/2001 Delivery of first LABORAS for Windows systems
- 2/2005 Introduction SONOTRACK
- 7/2005 Distributor SleepSign for Animals (EU)
- 8/2006 Introduction LABORAS 2.0
- 5/2007 Introduction SonoTrack 2.0
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- LABORAS is a fully automatic system for continuous behavior recognit=
ion
and tracking of small rodents (mice and rats)
- Replaces, reduces and refines behavioral scoring by human observers<=
/li>
- LABORAS sets a new standard in the area of behavioral observation
instruments
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- Monitoring of behavioral changes /effects after e.g.
- Drug treatment
- Efficacy and safety pharmacology
- Long term observations tests
- sleep-wake pattern, eat-drink pattern
- Experimentally induced behaviours
- Grooming, drinking, movement patterns, paw-licking, scratching
- toxicology
- Genetic modifications
- High Capacity Phenotyping transgenic mice
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- Configuration variables
- Up to to 8 measurement platforms connected to one computer
- Species: mice, rat or both
- Tracking and Behavior software modules:
- Tracking
- Normal behaviors
- Special behaviors
- Integration with Telemetry
- User interface specials
- GLP
- Independent start of the platforms
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- Tracking
- High resolution XY position track
- Velocity data (average, max.)
- Distance traveled
- Position distribution (details like favorite spots)
- Estimation of energy use (in development)
- Benefits of LABORAS high-resolution tracking
- provides accurate activity parameters
- replaces expensive instruments
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- Shows the importance of :
- Good animal behavior definition
- Proper definition of the experiment protocol
- And use of the LABORAS experiment administration
- Choice of pharmacological relevant behaviors
- Good correlation with the real behavior reference
- Not always human observer reference
- Result handling
- Recording and Presentation of result data
- Use of previous raw data/ result summaries
- Enabling the full benefit of LABORAS
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- General benefits to the experiment
- Tracking & behavior recognition combined in single system
- Standard and objective method
- Eliminates inter- and intra observer deviation
- Does not require trained or experienced raters
- Independent of light conditions (required for nocturnal animals)
- Home cage environment and non-evasive method
- Large scale observational experiments possible
- Continuous Test periods up to 7 days
- Growth potential to determine several new behavioral and tracking
parameters
- Experiment reduction by integrating behavior and physiology
- Reduction and refinement of experiments
- Reduces time & costs (>75% reduction)
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- Independent Validation Results
- Correlation with human observers (according to validation criterion)=
- Locomotion, Immobility > 90%
- Climbing, Grooming > 90%
- Eating, Drinking, Rearing > 80%
- Special behaviors > 80%
- Market share
- Since 2001 ± 250 platforms are delivered worldwide and over 30
references on our website support the value of LABORAS for the resea=
rch
community
- Customer base
- Our customer database includes large Pharmaceuticals:
GlaxoSmithKline, AstraZeneca, Merck, Amgen, Johnson &
Johnson, Takeda, Novo Nordisk, Solvay, Tanabe (ref. www.metris.nl)
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- SONOTRACK records, visualizes and plays back Ultrasound Calls
- SONOTRACK records the full spectrum from 15kHz up to 100kHz
- SONOTRACK records 4 independent ultrasound channels
- SONOTRACK can easily be adjusted to experimental environment and is =
easy
to use
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- Typical research areas:
- Pain
- Anxiety
- Depression
- Social interaction
- Animal Welfare
- Metris participates and invests to increase the application areaR=
17;s
for ultrasound
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- Playback of ultrasound as normal sound
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- Qualifications
- Only full spectrum Ultrasound recording and analysis instrument
designed for laboratory use
- Unrivalled, state-of-the-art technology
- Participation in several pilot studies
- Market share
- 17 systems in use worldwide (including two demo systems) since April
2005
- In 2007 first references
- Customer base
- Our customer database includes both large pharmaceutical companies (GlaxoSmithKline,
Amgen, Gedeon Richter) as well as reputable universities (Maryland
Univ., John Hopkins Univ., Tufts, Univ. of Toronto, Univ. of
Pittsburgh, Univ. Utrecht)
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- Metris offers:
- Fast assesments: < 25% of the time used for conventional
experimenting
- License key for both acquisition computer and second
“calculation” computer
- Highest quality for right decisions
- Accurate measurements (qualified equipment, proven definitions)
- (R)efinement of experiments (non-evasive, home cage, day/night)
- Easy to use experiment administration leads to traceable raw data<=
/li>
- Longterm assesments (up to 7 consequtive days)
- More experiments per animal (integration telemetry, ultrasound,
sleepstages and re-use of raw experiment data)
- (R)eduction of experiments and animals
- Raw data (only 1 MB per hour) can be re-used on new behavior modul=
es
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- With 6 year experience in automating animal behavior detection Metris
offers:
- Unique instruments enabling automation “ from treatment code =
to
dose response curve”
- Behavior detection modules defined & developed icw Pharmaceutic=
als
- Proven systems succesfully used
- Consultancy to optimize experiments
- Long term partnership to continuously improve in-vivo rodent
experimenting
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- Metris BV
- Kruisweg 801a
- 2132 NG Hoofddorp
- Phone: +31 23 5623400
- Fax: +31 23 5623425
- www.metris.nl
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